Some Effects of Edta and Tetraphenylboron on the Ultrastructure of Mitochondria in Mouse Liver Cells

Investigators who utilize tissue culture cells in viral, metabolic, and cytogenetic studies have generally overlooked the possible influences of cell-dispersing agents on their results. Our investigations, showing that EDTA and tetraphenylboron (TPB) cause extensive in vivo changes in the uhrastructure of several organelles of cells, will be piesented fully in a later report. Reported herein are some of the in vivo effects of these dispersing agents on the mitochondria of mouse liver cells.